Chengcheng Sang1, Li Ma1, Dong Luo, Hongxing Liu, Dan Li∗, Tianfeng Chen∗
Highlights:
• A novel pH-responsive Metal Azolate Framework-based nanosystem is designed and synthesized.
• The designed nanosystem can deliver therapeutic selenadiazole derivative to cancer cells with high-efficiency.
• The designed system can precisely and significantly inhibited tumor growth.
Abstract: Chemotherapy is one of the major cancer therapeutic approaches, however, it is limited by non-specificity, poor solubility, resistance. We reported here the use of bioresponsive nano metal azolate framework-4 (MAF-4) as vehicle materials and cRGD (cyclic arginine-glycine-aspartic) as target peptide to precisely deliver PSeD (selenadiazole derivative) to breast cancer cells. This intelligent nanosystem was stable at relatively basic pH (∼7.4, body fluid), while it slowly decomposed at slightly acidic pH (∼5.3, lysosomes) to release drug for precise treatment of breast cancer. The nanosystem specifically accumulated in tumors in vivo, and thus demonstrated high antitumor efficacy and non-toxic to normal tissues. Generally, this study indulged an innovative strategy for efficient cancer therapy using intelligent nanocarrier materials.
Keywords: Metal azolate framework; Nanosystem; Bioresponsive; Precise cancer therapy
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